Drawing on the realities of the heterogeneity and pluralities among the practitioners of South-South Cooperation (SSC) and acknowledging the significance to capture the nuances, this article argues against any effort to develop a uniform structure of methodological and accounting approaches. It further elaborates the importance of sectoral interventions in a mission mode that lies at the core of SSC interventions, unlike the project mode approach pursued under the official development assistance (ODA) framework. Underscoring the recent discussions in the literature that the world is moving towards a multiplex that would have no hegemonistic role for any nation, but would simultaneously preserve cultural and political diversity, it calls for moving beyond the idea of “Government to Government” approach to a more democratic process of “people-centric” cooperation. It concludes with the important role that think-tanks from the South are expected to play in strengthening SSC.